The Kaibai Creek (California) Massacre: Settlers of European heritage kill 42 indigenous Winnemem Wintu tribesmen, women, and children.

       [added 2/12/2022]

       The only thing I can say in defense of the settlers is that they brought their warlike European heritage with them and they also knew that the indigenous Americans could also be violent with any intruder, native or foreign.  –– JL

Subsequent Events:

References:

Native American Massacres – Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/Indian_Massacres

Current U.s. National Debt:

$36,161,621,015,445

Source