The Whitman Massacre: In Walla Walla, Federal enclave of Oregon (Washington), Cayuse tribesmen kill 13 Christian missionaries over a misunderstanding resulting from a mysterious illness that claimed the lives of several of Chief Tilaukait’s children. 

       [added 2/4/2022]

       Sorry about any loss of life, but maybe these Cayuse folks had heard about the French & Indian War, and the deliberate ‘gift’ of smallpox tainted blankets? –– JL